Depression and HIV Disease Progression: A Mini-Review

Abdilahi Yousuf 1, Siti Roshaidai Mohd Arifin2, *, Ramli Musa3, Muhammad Lokman Md. Isa4
1 College of Medicine and Health Sciences, Jijiga University , Jijiga,Ethiopia
2 Kulliyah of Nursing, IIUM, Selangor, Malaysia
3 Department of psychiatric, Kulliyah of medicine, IIUM, Selangor, Malaysia
4 Department Basic Medical Sciences, Kulliyah of Nursing, IIUM, Selangor, Malaysia

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Creative Commons License
© 2019 Yousuf et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License [CC-BY 4.0], a copy of which is available at: []. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Kulliyah of Nursing, IIUM, Selangor, Malaysia; Tel: +601133505235; E-mails:



Depression is the most common mental disorder and a leading cause of disability, which commonly presents unexplained psychological and physical symptoms. Depression and HIV/AIDS are commonly comorbid. This review provides an insight into the effect of depression on disease progression among people living with HIV.


A search for relevant articles was conducted using a database like MEDLINE, Scopus, PsycINFO and CINAHL. Peer-reviewed English journals published between 2015 and 2019 were included in the review.


A total of eight studies conducted in different settings were included in the review. This review has found that psychosocial, neurohormonal and virologic factors associated with depression affect HIV disease progression. Yet, the chronicity of depression, absence of the hormones that have a buffer effect on depression and lack of examination if depression is a predictor, or an outcome of disease progression, were some of the gaps that require further investigation.


Considerably, more research is needed to better understand the effect of mental disorder, especially depression, on HIV disease progression to AIDS and future interventions should, therefore, concentrate on the integration of mental health screening in HIV clinical setup.

Keywords: Risk factors, Depression, Anxiety, Mental health, Disease progression, HIV, AIDS.