Anti-Purkinje Cell and Natural Autoantibodies in a Group of Psychiatric Patients. Evidences for a Correlation with the Psychopathological Status

Roberto Delle Chiaie 1, 2, *, Brunella Caronti 1, 2, Francesco Macrì 1, Sandra Campi 1, Marzia Marino 1, Alessandra Corrado 1, Maria Caredda 1, 2, Massimo Biondi 1, 2
1 Departement of Neurology and Psichiatry, "Sapienza” University of Rome, Italy
2 Policlinico Umberto-I Hospital, Rome, Italy

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© Delle Chiaie et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Dipartimento di Neurologia e Psichiatria, “Sapienza” Università di Roma, Via Leone IV 38, (00192) Roma, Italy; Tel: 06-39742364; Fax: 06-39038466; E-mail:


Phenomena of autoimmunity are frequent among psychiatric patients, but we don’t know yet if they should be considered primary and linked to the pathophisiology of the disorder, or aspecific and associated to a general immune system activation. Paraneoplastic Cerebellar Degeneration (PCD) represents a well known model of specific autoimmunity. In order to better understand the abovementioned issues, we used this condition to compare a set of immune dysfunctions found in a group of psychiatric patients. For this reason we tested sera from 48 psychiatric patients (24 schizophrenics, 17 bipolars and 7 obsessive-compulsive), 22 PCD patients and 52 healthy controls for the presence of anti-Purkinje autoantibodies and of some natural autoantibodies (ANAs, AMAs, APCAs, ASMAs). Psychopatological status of the psychiatric patients was assessed with BPRS, SANS, SAPS, HAM-D, CGI-S. In the psychiatric group anti-Purkinje autoantibodies were identified in 11/48 (22,9%) patients, while they were present in 22/22 (100%) PCD patients and in 0/52 (0%) healthy controls. Among all anti-Purkinje autoantibody positive patients (in the PCD and psychiatric samples), only those belonging to the psychiatric sample, but not those with PCD, were frequently found positive also for natural autoantibodies, that are considered good markers of aspecific immune activation. In these patients, both anti-Purkinje and natural autoantibodies were found associated with acute/positive psychopathological symptoms. These results seem to point out that some phenomena of auto-immunity described in psychiatric patients could be aspecific, unrelated to the pathophysiology of the concomitant mental disorders and could be more frequent during phases of acute/positive symptoms.

Keywords:: Anti-Purkinje autoantibodies, Bipolar Disorder, HPA Axis, Natural autoantibodies, Obsessive Compulsive Disorder, Paraneoplastic Cerebellar Degeneration, Schizophrenia.