Differences Between Early and Late Onset Adult Depression
Jens Drachmann Bukha, *, Camilla Bocka, Maj Vinberga, Ulrik Getherb, Lars Vedel Kessinga
Identifiers and Pagination:Year: 2011
First Page: 140
Last Page: 147
Publisher ID: CPEMH-7-140
Article History:Received Date: 6/3/2011
Revision Received Date: 6/6/2011
Acceptance Date: 10/6/2011
Electronic publication date: 10/8/2011
Collection year: 2011
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
It is unclear, whether age-of-onset identifies subgroups of depression.
To assess the clinical presentation of depression with onset in the early adult age (18-30 years) as compared to depression with later onset (31-70 years).
A total number of 301 patients with first episode depression were systematically recruited. Characteristics including psychiatric co-morbidity, personality disorders and traits, stressful life events prior to onset, family history, and treatment outcome were assessed by structured interviews and compared by chi-square tests for categorical data, t-tests for continuous parametric data and Mann-Whitney U-test for continuous nonparametric data. Logistic and multiple regression analyses were used to adjust the analyses for potentially confounding variables.
Patients with early onset of depression were characterised by a higher prevalence of co-morbid personality disorders, higher levels of neuroticism, and a lower prevalence of stressful life events preceding onset compared to patients with later age-of-onset. There were no differences in severity of the depressive episode, treatment outcome or family loading of psychiatric illness.
Early adult onset of depression is associated with co-morbid personality deviances, whereas late onset is associated with environmental risk factors.