In 1931, Heintz Klinger, a medical student, first reported Wegener's granulomatosis disease, which encompasses a broad range of clinical manifestations [1]. Frederick Wegener provided a more comprehensive description of the disease and distinguished it from polyarteritis nodosa in 1936 [2]. The disease is characterized by inflammation of the upper and lower respiratory tracts, vasculitis, and glomerulonephritis. The most commonly affected areas include the upper respiratory tract, lungs, kidneys, skin, eyes, ears, orbits, joints, and lymph nodes, in that order of frequency [3]. During the initial stage of the disease, granulomatous mucosal inflammation primarily affects either the upper or lower respiratory tract, accompanied by vasculitis in the acute phase [4]. In the peripheral nervous system, cerebrovascular vasculitis can manifest as polyneuropathy or mononeuritis multiplex. The central nervous system (CNS) exhibits three distinct patterns: 1) vasculitis may affect the small to medium vessels of the brain or spinal cord during the general course of the disease, 2) granulomatous masses originating from the upper respiratory tract can invade adjacent cartilage and bone, causing damage to CNS structures, such as the ocular circuit and meninges in the brain, and 3) granulomatous lesions may develop within the brain tissue, such as in the meninges or brain itself [5].

Wegener's disease, an autoimmune condition with an unknown etiology [6], affects individuals across all age groups but shows a higher prevalence in middle-aged populations, affecting both men and women equally [7]. While comprehensive psychological and psychiatric studies specifically focusing on Wegener's disease patients are lacking, some research has explored the relationship between mental health and autoimmune diseases, such as systemic lupus erythematosus (SLE) [8]. Studies on SLE patients have shown that depressive and anxiety disorders are commonly observed [9]. Depression and anxiety also have a significant impact on heart disease and overall well-being in SLE patients [10]. Factors, such as specific autoantibody profiles, neurological damage, rashes, and cytokine concentrations have been identified as influencers of depression in patients with lupus. Additionally, certain socioeconomic factors, including psychological resilience, contribute to anxiety and depression in SLE patients [11]. High levels of stress, low social support, and psychological stress have negative correlations with the mental and physical health of patients with lupus [12]. Meszaros [2012] reported that more than 39% of patients with lupus experience depression, and over 80% exhibit cognitive dysfunction [13]. Anxiety disorders, cognitive dysfunction, mood disorders, and psychosis are recognized as psychological disorders in patients with lupus, as identified by the American College of Rheumatology [14]. Moreover, hyperactivity, attention deficit, and obsessive-compulsive disorder have been observed in patients with lupus [15]. Previous research has compared psychological disorders between patients with lupus and the general population, demonstrating that depression is four times more prevalent in patients with lupus, while anxiety is twice as common in this group, suggesting that anxiety is a reaction to the disease. Consequently, mental disorders exhibit a high prevalence among autoimmune patients, such as those with lupus. However, these conditions have received comparatively less attention, despite their significant impact on individuals' physical well-being and quality of life. For instance, anxiety and depression can exacerbate cardiovascular diseases, increase the risk of myocardial infarction, suicidal ideation, and mortality, and contribute to decreased quality of life, disability, and loss of employment [16].

Personality traits play a crucial role in understanding mental disorders, leading researchers to explore the relationship between personality and psychopathology. The Five-Factor Model has gained significant attention in classifying personality traits and their relevance to mental disorders. According to various personality trait theories, five major factors have been identified: neuroticism, extraversion, agreeableness, conscientiousness, and openness. These factors have been found to contribute to the development and maintenance of mental disorders [17]. Neuroticism is characterized by traits, such as instability, restlessness, and agitation. Extraversion is associated with boldness, high energy levels, and talkativeness. Openness includes traits related to imagination and intellectual curiosity. Agreeableness is characterized by reliability, cooperative behavior, and good manners. Finally, conscientiousness is associated with traits, such as trustworthiness and a strong sense of responsibility [18]. Several studies have also indicated a potential association between inflammation and personality traits. For instance, low levels of conscientiousness have been linked to increased levels of inflammatory markers, including C-reactive protein (CRP) and interleukin-6 (IL-6) [19].

Examining personality and its relationship with disorders enhances our understanding of risk factors, etiology, and therapeutic responses to diseases [20]. Personality serves as a key factor influencing individuals' adaptation and behavior in various environmental circumstances. In patients with chronic illnesses, emotional states and mood can be significantly impacted [21]. Additionally, it has a significant effect on pain experiences in patients with rheumatoid arthritis [22], and type D personality traits affect patients' quality of life and sleep [23]. Personality traits have the potential to predict the onset of psychiatric disorders [24] and play a substantial role in depression [25]. A study by Giannelou et al. demonstrated that extroverted personality traits and anxiety were independently associated with subclinical atherosclerosis in patients with lupus [26]. Research conducted by Gokcen et al. demonstrated that type D personality trait is associated with higher levels of anxiety and depression in patients with fibromyalgia [27]. Numerous investigations focusing on personality traits and psychopathology have revealed that psychiatric disorders are characterized by inconsistencies in personality traits [28]. Specifically, depression has been associated with three primary personality traits: high neuroticism, low extraversion, and low conscientiousness [29]. Moreover, personality traits play a crucial role in perceiving situations, events, and mental experiences of pain, influencing the occurrence, severity, and specific domains of psychological disorders [30].

To date, there has been a notable absence of comprehensive psychological investigations exploring the psychological and psychiatric factors in patients diagnosed with Wegener's disease. However, previous studies conducted on other autoimmune and rheumatologic conditions, such as lupus, have indicated a high prevalence of psychiatric disorders in these patient populations. Moreover, these studies have also highlighted the influential role of personality traits in the development and manifestation of psychological and psychiatric disorders. Building upon these findings, the objective of this study is two-fold: firstly, to determine the prevalence of psychiatric disorders among patients seeking treatment at the Amir Alam Hospital in Tehran, and secondly, to examine and predict the impact of personality traits on psychological and psychiatric disorders in these individuals.

We utilized Stata software version 14 for statistical analysis in order to assess the prevalence of psychiatric disorders among different groups based on marital status, gender, and educational background. Furthermore, we examined the prevalence of psychiatric disorders among patients with Wegener’s disease and investigated the predictive role of the big five personality traits in relation to these disorders. The study included a total of 75 patients with Wegener's disease, with an average age of 39.42 ± 10.78. Among these patients, 84% were married, and 70.7% were women. In terms of educational background, 30.7% had primary education, 33.3% had a diploma, 24% had a bachelor's degree, and 12% obtained higher education. Regarding the presence of mental illnesses, 12.2% of the participants reported a history of such disorders (Table 1).

Table 2 presents the prevalence of psychiatric disorders among the patients. The findings indicate that paranoid disorders (53.3%), depression (44%), somatization (42.7%), and obsessive-compulsive and anxiety disorders (37.33%) exhibited the highest prevalence rates. On the other hand, psychotic disorders (17.3%), hostility (25.33%), phobia (29.3%), and interpersonal sensitivity (30.7%) demonstrated the lowest prevalence rates among the study sample.

The results of the multivariate regression analysis revealed several significant findings. The normality of the data was assessed by examining the skewness and kurtosis values. According to the assumption that skewness should fall within the range of +/- 2 and kurtosis within the range of +/- 7, the data in this study were found to be normal [34, 35]. Firstly, somatization was found to be 0.37 units lower in men compared to women (P=0.028), and an increase in neuroticism was associated with higher levels of somatization (P=0.001). Additionally, an increase in neuroticism was found to be associated with higher levels of obsessive-compulsive symptoms (P=0.034).

Regarding sensitivity, a study found that for every one-year increase in age, sensitivity decreased by 0.02 units (P=0.026). Neuroticism and conscientiousness were identified as influential factors in sensitivity (P<0.001), with higher levels of neuroticism and conscientiousness being associated with increased sensitivity. However, agreeableness was found to have a negative effect on sensitivity (P=0.002), indicating that a one-unit increase in agreeableness led to a decrease of 0.05 in sensitivity.

Depression was significantly influenced by neuroticism (P<0.001) and conscientiousness (P=0.024). Specifically, a one-unit increase in neuroticism and conscientiousness was associated with a 0.06 and 0.05 increase in depression levels, respectively.

In terms of anxiety, neuroticism was the only factor that had a significant effect (P=0.008). As neuroticism increased, anxiety levels also increased. Similarly, agreeableness was the only factor found to have an effect on hostility (P=0.022), with the direction of the effect aligning with the nature of hostility.

Regarding phobic anxiety, men exhibited 0.30 units less phobic symptoms compared to women (P=0.045), and neuroticism was found to be a significant factor (P=0.004). Specifically, a one-unit increase in neuroticism led to a 0.04 increase in phobic symptoms.

Neuroticism (P<0.001) and agreeableness (P=0.006) were identified as factors significantly influencing paranoid symptoms. An increase in neuroticism was associated with higher levels of paranoia, while an increase in agreeableness was associated with lower levels of paranoia.

Finally, neuroticism was found to have a significant effect on psychotic symptoms (P=0.004). A one-unit increase in neuroticism resulted in a 0.04 increase in psychotic symptoms (Table 3).

The higher prevalence of psychiatric disorders observed in patients with Wegener’s disease compared to the general population is consistent with findings from previous studies on individuals with chronic diseases. Mood disorders and anxiety are known to be more prevalent among individuals with chronic conditions compared to healthy individuals in the community. As Wegener's disease is a chronic condition, it is expected that the prevalence of these psychiatric disorders would be elevated in patients suffering from Wegener’s disease, making the study of psychiatric disorders in this population particularly significant. In our study, the most prevalent psychiatric disorders among patients with Wegener’s disease were found to be paranoid disorder, depression, somatization, obsessive-compulsive disorder, anxiety, interpersonal sensitivity, phobic anxiety, hostility, and psychosis, in descending order. The prevalence of these disorders in our sample was higher than the reported prevalence in the general population of Iran based on previous studies [36-38]. This suggests that patients with Wegener’s disease may be at a heightened risk for developing psychiatric disorders compared to the general population. To the best of our knowledge, no previous study has comprehensively assessed the prevalence of psychiatric and psychological disorders, specifically in patients with Wegener’s disease. However, a study conducted by Rula et al. [2011] on these patients reported a 22% prevalence of depression disorders, which is consistent with our findings [39]. Studies conducted on other rheumatic diseases, such as lupus, have consistently demonstrated higher rates of depression and anxiety compared to the general population. Individuals with medical illnesses generally experience more psychological distress due to the challenges and impact of the chronic disease on their lives [13, 40]. Chronic diseases like Wegener's disease pose ongoing challenges and disruptions to a person's life. The diagnosis itself can be seen as a significant life challenge, and some patients may struggle to cope with these challenges, leading to an increased vulnerability to developing psychological disorders. The diagnosis of psychiatric comorbidity in granulomatosis with polyangiitis presents some challenges, as the overlap of psychiatric symptoms with the physical manifestations of the autoimmune disease can complicate the identification of distinct mental health issues [41]. Additionally, the variable and evolving nature of psychiatric symptoms in granulomatosis with polyangiitis further complicates diagnostic efforts. Overall, our findings highlight the importance of recognizing and addressing psychiatric disorders in patients with Wegener’s disease. In a clinical context (like a hospital), early identification and appropriate management of these disorders are crucial in providing comprehensive care for individuals with Wegener's disease and improving their overall well-being. Future research should aim to better describe the phenomenology of psychiatric signs and symptoms and continue investigating the specific factors contributing to the development and maintenance of psychiatric disorders in this population and explore effective interventions to support their mental health.

Wegener's disease is an autoimmune condition influenced by various factors, including genetics, hormones, and the environment. Research has demonstrated that mental states, such as mental stress and depression, can contribute to the acceleration of inflammation and autoimmune diseases [42]. There is a known association between the immune system and mental disorders, such as anxiety, depression, schizophrenia, and bipolar disorder. These disorders have been linked to the dysregulation of T cell functions and the presence of proinflammatory cytokines, including interleukin‐6 (IL‐6), IL‐2 receptor, IL‐1β, IL‐17A, and C‐reactive protein [43]. T cell function and proinflammatory cytokines play a vital role in the pathogenesis of Wegener's disease [44]. The high prevalence of psychiatric disorders in Wegener's disease can also be attributed to the presence of proinflammatory factors, which are common to both psychiatric disorders and Wegener's disease. These shared factors may contribute to the increased risk and occurrence of psychiatric disorders in individuals with Wegener's disease. Understanding the relationship between psychiatric disorders and autoimmune diseases like Wegener's disease is important, as it sheds light on the complex interplay between the immune system, inflammation, and mental health. Further research is needed to explore the underlying mechanisms connecting these disorders and to identify potential therapeutic targets for managing psychiatric symptoms in individuals with Wegener's disease. By addressing both the physical and mental aspects of the disease, more comprehensive care can be provided to individuals with Wegener's disease, leading to improved overall outcomes and quality of life.

The second aim of this study was to examine the predictive role of personality traits in psychiatric disorders in patients with Wegener's disease. The results indicated that the personality trait of neuroticism positively predicted most psychiatric disorders. Specifically, an increase in neuroticism traits was associated with a higher likelihood of experiencing psychiatric disorders. These findings are consistent with previous research conducted by Malouff et al. [2005], which demonstrated a link between clinical disorders and high levels of neuroticism, as well as low levels of conscientiousness, agreeableness, and extraversion. Individuals possessing these personality traits tend to be more susceptible to clinical psychological disorders [45]. Similar results were observed in a study conducted by Habibi et al. [2013] on personality traits and mental health in individuals with addiction. Their findings align with our study, highlighting the significant relationship between personality traits and various psychological disorders [46]. Additionally, Koh et al. [2015] reported that neuroticism personality traits were associated with higher levels of depression, anxiety, and somatization. Individuals exhibiting high levels of neuroticism were more prone to experiencing anxiety, depression, and somatization symptoms [47]. These consistent findings across studies suggest the importance of considering personality traits, particularly neuroticism, in the understanding and prediction of psychiatric disorders. Recognizing the role of personality traits can contribute to the development of targeted interventions and treatment approaches for individuals with Wegener's disease and other psychiatric conditions. Therefore, further research is needed to explore the underlying mechanisms linking personality traits and psychiatric disorders and to investigate potential interventions that may help mitigate the impact of these disorders on individuals' well-being.

The vulnerability hypothesis suggests that personality traits contribute to a general vulnerability, increasing the likelihood of experiencing multiple psychological disorders. Additionally, the pathoplasty model proposes that personality factors influence the course and severity of psychological trauma, although they do not establish a causal relationship [48]. Personality traits have an impact on our perception of events, the environment, and individuals' subjective experience of pain [49]. One specific personality trait discussed in this study is neuroticism, characterized by emotional reactivity and negative responses to threats, frustration, and loss. Neuroticism is associated with irritability, anger, sadness, anxiety, worry, and a propensity for violence. Individuals high in neuroticism tend to exhibit negative and disproportionate reactions to life challenges, such as illness [50]. Overall, neuroticism is associated with deviant behavioral and cognitive patterns and elevated stress levels, which contribute to the development of psychological disorders [48]. Neuroticism is linked to various psychological factors, including anxiety, depression, pessimism, feelings of hopelessness, impulsivity, aggression, low self-esteem, vulnerability to stress, and chronic negative emotions [51]. Neurotic individuals are more prone to experiencing negative emotions, stress, and mental distress [30]. Another personality trait of interest is agreeableness, which encompasses attributes, such as self-sacrifice, cooperation, helpfulness, patience, flexibility, generosity, and compassion [52]. Individuals high in agreeableness demonstrate these characteristics more prominently in their personalities. It has been suggested that agreeableness plays a fundamental role in maintaining positive interpersonal relationships and minimizing conflicts. In other words, individuals with high agreeableness tend to engage in positive behaviors and establish harmonious relationships with others, compared to those with lower levels of agreeableness who may exhibit more provocative behaviors [53]. Several researchers have emphasized the significance of agreeableness as a fundamental concept in assessing individual differences [54]. Agreeableness plays a motivating role in fostering interpersonal relationships and minimizing conflicts. Individuals high in agreeableness strive to exhibit positive behaviors and cultivate harmonious relationships while minimizing provocative actions towards others [53]. Conversely, individuals with difficulties in social relationships and a tendency towards isolation face an increased risk of mental disorders. This suggests a close association between social relationships and mental health issues [55]. Consequently, individuals with lower levels of agreeableness may encounter challenges in their social interactions, rendering them more susceptible to psychological disorders. Conscientiousness, another personality trait, is characterized by attributes, such as responsibility, trustworthiness, and discipline in individuals [56]. Conscientiousness has been found to positively correlate with overall life performance, self-efficacy, and individual achievements. Higher levels of self-efficacy are associated with a lower prevalence of psychiatric disorders [47]. However, the results of this study demonstrated a positive relationship between conscientiousness and certain disorders, such as depression. It is possible that the disease itself and the physical conditions of the patients may have influenced these findings. Therefore, conducting more extensive investigations on the personality traits of patients with Wegener’s disease in future studies is recommended. Wegener’s disease is an autoimmune condition involving the immune system. As mentioned, psychiatric disorders are associated with immune system dysfunction. Consequently, it is advisable to consider psychology and psychiatry interventions alongside physical activities to address the psychological impact of Wegener's disease.

The present study had certain limitations that need to be acknowledged. Firstly, the low prevalence of Wegener's disease posed challenges in accessing an adequate number of patients for the study. Consequently, the sample size was relatively small, which may limit the generalizability of the findings. To overcome this limitation, it is recommended that future studies include samples from multiple provinces or regions to enhance the representativeness of the results and provide a more comprehensive understanding of psychiatric disorders in Wegener's disease.

In conclusion, the findings of this study highlight the increased prevalence of mental disorders among individuals with chronic diseases, such as Wegener's disease. The impact of these diseases on individuals' personal and social lives, coupled with the physical burden they impose, contributes to the elevated rates of mental disorders observed in this population. Among the various psychological factors that influence the development of mental disorders, personality traits play a significant role. Specifically, harmful personality traits like neuroticism are associated with a higher likelihood of experiencing psychological disorders, whereas positive traits, such as extraversion, serve as protective factors against mental disorders. Therefore, it is crucial to identify these personality traits and mental disorders in patients with Wegener's disease in a timely manner and implement necessary interventions to improve their mental well-being. By addressing these factors, healthcare professionals can enhance the overall quality of life for individuals living with chronic diseases and promote better mental health outcomes. Further research and interventions focused on understanding and managing personality traits and mental disorders in this population are warranted.