Depression Among the Caregivers of Breast Cancer Patients and its Association with the Quality of Life

Suzie Y. Rababa’h1, *, Karem H. Alzoubi2, 3, Laiali Alquraan4, Reema Karasneh5, Sayer I Al-azzam3, Nasr Alrabadi6
1 Department of Medical Science, Irbid Faculty, Al-Balqa Applied University (BAU), Irbid, Jordan
2 Department of Pharmacy Practice and Pharmacotherapeutics, University of Sharjah, Sharjah, UAE
3 Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
4 Department of Biology, Yarmouk University, Irbid, Jordan
5 Department of Basic Medical Sciences, Yarmouk University, Irbid, Jordan
6 Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

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© 2022 Rababa’h et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Medical Science Irbid Faculty, Al-Balqa Applied University (BAU), Irbid, Jordan; E-mail:



This study investigated the prevalence of depression among the Jordanian caregivers of patients with breast cancer and its effect on their health-related quality of life (QOL).


This was a cross-sectional study with a sample that consisted of 122 caregivers recruited from 2 hospitals in Jordan over 5 months. A validated questionnaire was used to assess the prevalence of depression symptoms and the aspects of QOL among the participants using Beck’s Depression Inventory-II score and the 36-Item Survey Form (SF-36) score.

Results and Discussion:

Depression symptoms were revealed in 27.9% of caregivers. Regarding the QOL, the mental health (MH) subscale was considerably associated with caregivers’ age (P=0.007). The marital status of caregivers was significantly associated with pain (Bodily Pain BP) (P=0.015), Beck’s Depression Inventory (BDI; P=0.009), and social functioning (SF) (P=0.008). The number of caregivers’ siblings was considerably associated with MH (P=0.040) subscale. The monthly income of caregivers was associated with BP (P=0.042). The residency of caregivers was considerably connected with role limitations because of emotional problems (RE) (P=0.027) and role limitations due to physical health (RF) (P=0.013) subscales. There was a significant correlation between the existing family history of depression with RF (P=0.009), RE (P=0.005), SF (P=0.003), and energy/fatigue (Vitality VT) (P=0.001) subscales. Furthermore, the physical activity of caregivers was connected with the RF (P=0.030), general health (GH) (P=0.018), RE (P=0.015), and MH (P=0.003) subscales.


Around a third of the caregivers revealed depression symptoms. The QOL subscales for these caregivers were connected with various health and social factors, such as age, number of siblings, marital status, monthly income, residency, family history of depression, and physical activity. The evaluation of the mental and physical well-being of caregivers should always be considered and managed to help them to cope with their QOL.

Keywords: Beck’s depression inventory, Breast cancer caregivers, Caregiver quality of life, Depression, SF-36, Patients.


Breast cancer is a worldwide public health burden [1, 2], and the second in death cases among Jordanians after cardiovascular diseases [3]. The role of the caregivers is very demanding and affects their mental and physical well-being [4]. Case-control studies revealed the devastating effect of work stress on mental health, especially depression, among caregivers [5, 6]. Caregiving for the vulnerable elderly has been described as a stressful phase that can lead to a lack of mental and physical health of caregivers [7]. Several studies demonstrated a variety of stressors that caregiver health and QOL are affected by, including social, mental functioning, or physical health [8, 9] and behaviors such as reduced exercise or rest and ignoring themselves while working with those patients with breast cancer [9].

Some other studies also revealed that the rate of depression among caregivers of cancer

patients were greater than that of the general population [6, 8, 9]. Moreover, they reported that cancer care can lead to an increase in the risk of sleep disturbances, anxiety, depression, and end with decrements in QOL [6, 10]. A cross-sectional study of psychological distress among cancer patients and their family caregivers revealed that both members developed the same levels of distress [11]. This study aims to estimate the prevalence of depression among caregivers and its impact on the mental and healthy functioning of the caregivers of breast cancer patients in Jordan.


This study was a cross-sectional where a survey was distributed to the Jordanian caregivers of breast cancer patients between May 2019 and September 2019 at King Abdullah University Hospital (KAUH) and King Hussein Medical Center, which are tertiary care facilities in Jordan hosting more than 400 beds each. The sample of the study included a total of 122 (54 females and 68 male) caregivers of breast cancer patients. The study was approved by the institutional review board at the Jordan University of Science and Technology, Irbid-Jordan (Approval number 66/2018). Informed consent has been obtained from the study participants and Helsinki Declaration has been followed for the study. The participants were interviewed after being introduced to the aim of the study and accepted to provide signed informed consent. The study questionnaires included one for sociodemographic information, another, which was the 36 QOL Short Form (SF-36) Scale, and the third one, which was based on Beck’s Depression Inventory (BDI), concerned with evaluating depression status.

2.1. The Sociodemographic Questionnaire

This questionnaire consisted of several questions concerning the caregiver participants' sociodemographic characteristics. It included demographic data, socioeconomic status, the presence of insurance for caregiver cancer patients, and participants’ place of living. It was administered to participants through face-to-face interviews.

2.2. The 36 QOL Short Form (SF-36) Scale

The self-rating SF-36 QOL scale included 36 questions measuring the eight aspects or dimensions of the QOL. Each subscale or aspect is measured separately with scores starting from 0 (representing poor and deteriorated QOL) and reaching 100 (representing the optimum QOL). It is worth mentioning that a total score cannot be calculated and each sub-score should be measured separately [12].

2.3. Beck Depression Inventory (BDI)

BDI is similarly, a rating scale, used for both apparently healthy and psychiatric patients. This scale can be employed to identify depression among the participants and to measure the change in its severity. Each question on the 21 questions scale was given a weight between 0 and 3 points; therefore, the total score is expected to range between 0 and 63. However, the threshold of the scale cut-off point was set to 17 in the previous validity and reliability Turkish study [13].

2.4. Statistical Analysis

The SPSS 16.0 statistics package program (SPSS Inc., Chicago, IL, USA) was used to analyze the collected data. Numerical variables were expressed as means ± standard deviation and categorical variables were expressed as frequencies. The difference between variables was considered significant when the calculated P-value was < 0.05. ANOVA test and Student’s t-test were used for the numerical variables to compare between groups, while Chi-square test and Pearson’s correlation analysis were used when analyzing the data on categorical variables. The correlation coefficient (r) was considered weak when it was from 0.000 to 0.249; moderate from 0.250 to 0.499; and strong from 0.500 to 0.749. While a very strong relationship was considered when it was between 0.750 and 1.000.


The number of breast cancer caregivers who participated in this study was 122 (n=54 females and 68 males. Almost two-thirds of the caregivers’ participants were married (59.8%), without children, and employed (63.1%). Moreover, a high proportion of caregivers finished high school education (46.7%), while merely 3.3% of caregivers were illiterate. Table 1 summarizes the demographic information of the caregivers' participants. The predominance of depression among patients was 27.9%. As shown in Table 2, it is distributed as 21.3% with mild depression, 13.1% with moderate depression, and 8.2% with severe depression.

The reliability, variability of scales, and central tendency of the SF-36 QOL survey among the caregivers were shown in Table 3. Whereas the association between the study variables and the SF-36 QOL subscales was shown in Table 4. An association between the age of the patients and the MH scale was found (P=0.007). A link was found between the marital status of caregivers and the BP (P=0.015), the BDI (P=0.009), and the SF (P=0.008). As well, the siblings’ number of those caregivers was considerably connected with the mental health (P=0.040) subscale. Moreover, the monthly income of caregivers was associated with BP (P=0.042).

The living place or residency of caregivers was noticeably connected with the RF (P=0.013) and RE (P=0.027) subscales. Caregivers’ educational level, profession, and average sleep hours during the day were not associated with any subscale of the SF-36 QOL questionnaire. Regarding the status of depression, having a history of depression among family members was associated with RF(P=0.009), RE (P=0.005), SF (P=0.003), and VT (P=0.001) subscales. Besides, the physical activity of caregivers was connected with the RF (P=0.030), GH (P=0.018), RE (P=0.015), and MH (P=0.003) subscales. As a final point, the BDI-II index displayed a substantial relationship with marital status (P=0.009) as displayed in Table 4.

Table 1. Demographic Features of Caregivers for Breast Cancer Patients (N=122).
Demographic Features Frequency Percent%
Female 54 44.3
Male 68 55.7
18-30 40 32.8
31-40 38 31.1
41-50 18 14.8
>50 26 21.3
Jordanian 120 98.4
Others 2 1.6
Marital status
Married 73 59.8
Single 38 31.1
Others 11 9.0
Number of siblings
None 42 34.4
1-2 26 21.3
3-4 32 26.2
5-6 13 10.7
>6 9 7.4
Illiterate 4 3.3
Primary school 10 8.2
Secondary school 57 46.7
Undergraduate 46 37.7
Graduate studies 5 4.1
Employed 77 63.1
Unemployed 17 13.9
Housewife 28 23.0
Monthly income (JD)
<250 30 24.6
250-500 56 45.9
>500 36 29.5
Living area
Urban 78 64.5
Rural 43 35.5
Average sleep hours/day
<4 12 9.9
5-6 51 42.1
7-8 52 43.0
>8 6 5.0
Family history of depression
Yes 19 15.6
No 103 84.4
Smoking status
Smoker 37 30.3
None smoker 85 69.7
Regular physical activity
Yes 24 19.8
No 97 80.2
Chronic Diseases
Diabetes 13 10.8
Hypertension 15 12.5
Cardiovascular diseases 4 3.3
Respiratory diseases 7 5.8
Obesity 6 5
Others 12 10
Reference person if depressed
Family and friends 57 47.9
Health care provider 11 9.2
Social advisor 7 5.9
44 37.0
Table 2. Beck’s depression inventory average -categories and subscales (Cronbach Alpha= 0.884).
- No. Percent%
BDI mean ± SD (range) 12.90 ±9.48 (0-46)
Minimal range (0-13) 70 57.4
Mild (14-19) 26 21.3
Moderate (20-28) 16 13.1
Severe (29-63) 10 8.2
   Depression (17 cut off point) *
Note: * “Hisli N. Use of the Beck depression ınventory with Turkish üniversity students: Reliability, validity, and factor analysis. Turk J Psychol. 1989; 7:3–13”.
Table 3. Scales of SF-36 quality of life questionnaire of breast cancer patients’ caregivers.
- Items Alpha Mean ± SD
Physical functioning (PF) 10 0.909 69.67±28.87
Role limitations because of physical health (RF) 4 0.862 61.98±40.96
Role Limitations-emotional problems (RE) 3 0.888 62.53±44.00
Energy (Vitality VT) 4 0.708 57.34±21.33
Emotional wellbeing 5 0.803 63.11±23.08
Social functioning (SF) 2 0.657 72.31±25.32
Pain 2 0.746 75.70±24.75
General health (GH) 5 0.375 63.65±16.22
Health change 1 ---- 52.89±26.85
Table 4. Sociodemographic characteristics of caregivers of breast cancer patients with the short form 36 and the parameters pf Becks depression inventory (N= 122).
- PF           RF           RE VT MH SF BP GH BDI
Male 71.39±28.57           71.30±37.12           73.46±39.59 61.85±22.87 66.44±23.64 73.84±27.18 84.12±19.46 67.41±15.44 12.69±10.46
Female 68.28±29.25           54.48±42.62           53.73±45.67 53.71±19.43 60.42±22.44 71.08±23.86 68.92±26.54 60.67±16.32 13.07±8.69
P NS           0.024           0.014 0.036 NS NS 0.001 0.022 NS
18 – 30 61.41±34.12           50.00±39.74           52.14±45.11 53.68±20.15 57.03±22.30 69.23±26.57 71.47±26.27 63.88±15.13 15.25±9.67
31-40 75.13±26.82           72.37±37.57           64.91±43.11 55.26±21.02 60.95±23.74 72.37±26.02 78.75±24.44 61.18±16.25 13.84±10.67
41-50 68.33±27.33           70.83±41.35           59.26±47.90 58.06±23.40 61.56±25.96 76.39±20.96 68.33±28.04 64.17±20.38 10.83±8.73
>50 75.00±21.82           58.65±44.13           76.92±38.61 65.38±21.12 76.46±16.01 74.04±25.96 82.69±18.44 66.54±15.02 9.35±6.49
P NS           NS           NS NS 0.007 NS NS NS NS
Marital status
Married 70.35±27.71           67.04±39.54           68.06±42.03 59.72±21.08 66.78±23.22 75.00±23.46 80.56±21.16 64.66±16.84 11.05±9.40
Single 71.58±30.74           57.90±40.73           55.26±45.37 55.35±21.70 57.79±22.0 69.08±27.68 71.58±25.29 62.50±15.63 14.79±8.95
Others 58.64±30.09           43.18±47.55           51.52±50.25 48.64±20.63 57.45±23.07 65.91±28.55 58.18±35.13 60.91±14.80 18.64±8.99
P NS           NS           NS NS NS 0.008 0.015 NS 0.009
Number of siblings
None 67.38±30.91           57.74±39.62           52.38±44.87 54.64±21.54 56.10±21.34 70.83±27.42 68.99±26.49 63.10±15.85 15.07±8.40
1-2 68.65±30.94           69.23±42.02           70.51±44.55 59.23±21.20 65.08±25.56 78.37±22.52 80.67±25.68 63.65±16.94 13.46±10.26
3-4 71.41±25.22           61.72±43.06           68.75±42.28 56.56±22.56 64.63±24.62 71.48±25.64 80.39±18.06 63.28±16.29 12.81±10.82
5-6 68.08±30.38           63.46±36.25           56.41±41.69 56.15±16.85 66.46±15.54 72.12±18.51 77.69±24.53 63.08±16.40 7.0±5.45
>6 80.63±26.25           59.38±49.89           75.0±46.29 70.42±21.96 82.0±16.84 64.06±32.35 72.81±32.85 68.33±18.37 10.0±8.85
P NS           NS           NS NS 0.040 NS NS NS NS
Illiterate 40.0±52.20           75.0±25.0           77.78±38.49 58.33±27.54 64.0±22.27 79.17±36.08 81.67±31.75 67.50±27.54 6.0±3.92
Primary school 68.0±28.01           55.0±45.34           53.33±50.18 55.0±12.47 52.40±23.88 53.75±28.29 71.0±22.86 57.50±12.08 11.0±8.51
Secondary school 68.25±29.02           67.54±39.52           64.33±43.58 54.27±20.73 60.42±23.59 75.22±22.84 72.76±27.29 62.19±16.28 14.35±9.29
Undergraduate 74.46±27.71           53.80±43.45           60.87±45.16 61.52±23.33 67.65±22.18 72.55±26.56 78.53±22.12 65.54±15.99 12.65±10.14
Graduate studies 63.0±20.80           80.0±20.92           66.67±40.82 58.0±20.80 72.80±19.47 70.0±22.71 89.0±15.47 72.0±14.40 8.0±7.75
P NS           NS           NS NS NS NS NS NS NS
Employed 72.21±26.41           64.29±40.84           69.70±41.25 58.96±22.37 65.14±22.72 72.56±25.25 77.63±24.50 64.74±16.12 12.65±9.83
Unemployed 74.71±30.02           66.18±42.33           52.94±47.23 55.20±21.47 62.59±22.22 73.53±27.20 72.50±28.93 62.35±14.37 14.18±8.55
Housewife 59.26±33.24           52.78±40.63           48.15±46.53 54.07±18.24 57.63±24.54 70.83±25.24 72.22±22.94 61.42±17.78 12.82±9.29
P NS           NS           NS NS NS NS NS NS NS
Monthly income (JD)
<250 61.83±29.93           63.33± 40.33           61.11±46.39 56.78±20.62 60.27±22.50 77.50±22.60 67.75±29.45 61.50±15.09 14.73±8.23
250-500 68.73±29.52           59.09±41.21           58.18±44.55 55.27±20.98 60.95±23.66 68.86±26.45 75.23±24.04 62.68±15.98 13.02±10.09
>500 77.64±25.54           65.28±41.95           70.37±41.23 60.97±22.55 68.78±22.26 73.26±25.56 83.06±19.48 66.94±17.41 11.19±9.41
P NS           NS           NS NS NS NS 0.042 NS NS
Current location
Urban 69.04± 28.46           55.13±43.09           55.9829±45.74 57.44±22.56 61.33±25.30 69.87±25.28 74.13±25.44 62.76±17.22 13.94±10.10
Rural 70.81±29.92           74.42±33.85           74.42±38.38 57.17±19.16 66.33±18.21 76.74±25.09 78.55±23.47 64.44±13.46 11.16±8.12
P NS           0.013           0.027 NS NS NS NS NS NS
Average sleep hours/day
<4 62.50±29.81           54.17±45.02           38.89±48.89 50.00±20.11 51.67±21.74 77.08±24.33 59.58±32.91 55.41±17.90 17.50±7.22
5-6 65.60±32.15           58.00±41.17           63.33±42.19 58.70±24.59 63.68±26.23 70.25±25.11 77.00±22.71 64.80±16.70 13.69±10.90
7-8 73.17±25.88           66.35±40.80           66.03±44.52 57.60±16.99 64.08±20.09 73.32±25.96 76.83±24.83 63.65±15.34 10.67±7.27
>8 84.17±18.55           66.67±37.64           66.67±42.16 59.17±31.69 72.67±21.08 70.83±30.28 85.47±13.36 70.83±15.30 13.50±12.87
P NS           NS           NS NS NS NS NS NS NS
Family history of depression
Yes 67.89±26.79           39.47±43.55           36.84±42.88 42.02±19.76 44.63±22.76 56.58±23.71 57.12±27.65 50.00±13.94 21.21±11.57
No 70.00±29.35           66.18±39.28           67.32±42.73 60.17±20.46 66.55±21.55 75.25±24.62 79.17±22.67 66.17±15.39 11.37±8.23
P NS           0.009           0.005 0.001 0.000 0.003 0.000 0.000 0.000
Smoking status
Smoker 70.95±24.86           57.43±42.84           59.46±43.84 53.92±21.45 57.84±25.93 70.61±25.55 78.31±24.35 60.41±24.35 15.00±16.93
None smoker 69.11±30.60           63.99±40.21           63.89±44.27 58.85±21.24 65.43±21.46 73.07±25.34 74.56±24.98 65.06±15.80 11.99±8.12
P NS           NS           NS NS NS NS NS NS NS
Physical activity
Yes 71.25±29.86           78.13±31.55           81.94±31.05 63.33±18.75 75.50±20.27 78.13±23.67 79.38±22.68 70.21±12.29 10.29±6.87
No 69.28±28.77           57.99±42.17           57.73±45.53 55.86±21.76 60.04±22.79 70.88±25.63 74. 80±25.26 61.65±16.34 13.61±9.97
P NS           0.030           0.015 NS 0.003 NS NS 0.018 NS
Chronic diseases
Yes 70.0±25.74           48.08±41.41           69.23±39.58 50.38±19.84 59.08±23.73 72.12±21.74 72.88±20.71 48.08±17.39 16.62±12.31
No 69.72±29.21           62.97±40.86           61.01±44.71 57.77±21.42 62.98±22.84 71.82±25.77 75.59±25.27 65.42±15.25 12.62±9.05
P NS           NS           NS NS NS NS NS 0.000 NS
Yes 73.67±17.88           65.0±39.87           66.67±39.84 58.0±16.23 61.33±26.35 71.67±20.30 70.33±22.75 56.33±21.91 13.07±8.06
No 69.18±30.02           60.82±41.33           61.22±44.82 56.81±22.0 62.73±22.46 71.88±26. 0 76.01±25.05 64.57±15.24 13.05±9.69
P NS           NS           NS NS NS NS NS NS NS
Cardiovascular diseases
Yes 71.25±27.80           75.0±50.0           75.0±50.0 52.08±10.31 68.0±10.33 71.88±15.73 61.88±33.69 50.0±7.07 15.0±11.52
No 69.70±28.90           60.87±40.84           61.45±44.07 57.13±21.58 62.37±23.18 71.85±25.59 75.76±24.45 64.01±16.38 12.98±9.45
P NS           NS           NS NS NS NS NS NS NS
Respiratory diseases
Yes 70.71±25.89           64.29±34.93           61.90±48.80 43.33±15.81 66.86±14.92 67.86±18.90 65.71±29.07 59.29±7.32 16.29±7.11
No 69.69±29.03           61.16±41.49           61.90±44.04 57.81±21.36 62.29±23.30 72.10±25.67 75.90±24.48 63.81±16.72 12.85±9.58
P NS           NS           NS NS NS NS NS NS NS
Yes 78.33±12.11           75.0±31.62           66.67±42.16 44.17±7.36 58.67±16.72 83.33±15.14 70.0±18.91 54.17±19.60 11.83±5.15
No 69.29±29.33           60.62±41.43           61.65±44.37 57.64±21.59 62.76±23.19 71.24±25.60 75.58±25.06 64.03±16.10 13.11±9.66
P NS           NS           NS NS NS NS NS NS NS
Reference person if feeling depressed
          Family and friends 70.80±26.54           63.84±39.86           67.86±42.15 58.84±19.75 62.93±19.85 73.21±23.65 74.46±26.37 63.42±15.79 12.44±9.21
          Health care provider 72.73±26.68           47.73±50.56           60.61±49.03 58.18±23.16 63.27±23.85 63.64±24.66 88.18±18.20 58.64±20.01 15.09±10.15
          Social advisor 71.43±39.76           78.57±36.60           76.19±41.79 62.62±14.27 80.57±8.77 85.71±15.19 76.07±30.34 76.43±17.01 13.29±10.10
          No one 66.48±31.38           58.52±41.04           53.03±45.65 53.18±23.73 58.55±26.63 69.89±28.57 73.18±23.52 62.16±14.92 13.41±9.76
          P NS           NS           NS NS NS NS NS NS NS
Note: The study used One-way ANOVA to compare variables with three or more categories, whereas it used unpaired t-test for two-group variable.
Abbreviations: RP, role-physical; RE, role-emotional; PF, physical functioning; VT, vitality; MH, mental health; BP, bodily pain; SF, social functioning; BDI, Beck’s Depression Inventory; GH, general health; JD, Jordanian Dinar (=0.71 US Dollars).


The current study investigated the level of depression and its association with QOL among breast cancer caregivers in Jordan. In line with the cut-off points of the BDI-II rating scale, which was employed to reveal the level of depression and its severity among the caregivers of breast cancer patients, 27.9% of the participants showed clear depression symptoms. Those participants were categorized as follows: caregivers with mild symptoms of depression (21.3%), caregivers with moderate symptoms of depression (13.1%), and caregivers with severe symptoms of depression (8.2%). Considerably, the symptoms of depression among the participating caregivers were significantly linked to their marital status.

A previous study has revealed that the prevalence of depression among breast cancer caregivers was 24.8%)mild, moderate, and severe) in Iran region [14]. Another study, using a validated instrument, showed that approximately 42% of the caregivers for cancer patients were suffering from depression symptoms. This high level of depression prevalence probably affects the QOL of the caregivers [15, 16]. A systematic review using 19 studies focusing on the needs, intervention, motivation of caregivers, and even the consequences of caregiving [17], revealed that the most important correlations with QOL among caregivers were employment status, income, and the severity of their disease. Moreover, the psychosocial challenges were the most predominant among those caregivers [17-19].

The present study compared patients concerning different age groups with the subscales of the SF-36 scoring system; mental health scores of old caregivers were considerably revealed lower than young caregivers. Studies from the literature have revealed a significant and immediate reduction in mental health status after the caregiver period [5, 20] such as the study from Iran which showed that caregivers of breast cancer women who were also family members reported high effects on their quality of life including high psychological stress directly after diagnosis and the subsequent few months [21]. Results of the present study showed that the caregivers (married, single, or others) had reduced scores in BDI-II and social functioning, while their mean bodily pain scores were considerably higher (P < .015). A new study reported that the most widespread problems of physical nature that were expressed by caregivers involved pain, sleep disturbances, fatigue, loss of appetite, loss of physical strength, loss of physical strength, and weight loss [22].

An Australian study reported the direct physical health impact of caregiving, including back, shoulder, and neck problems, tiredness and exhaustion, weight problems, leg and foot problems, arthritis, and stress-related diseases [23, 24]. Another study by Grbich et al. (2001)identified that caregivers generally reported strain off the legs and back, with constant tiredness feeling from lifting their patients.

The present study revealed that a higher number of siblings tended to be connected with emotional well-being. Other studies indicated that positive relationships between caregivers and patients and family members were critical as caregivers’ burden becomes important during the period of patients with end-life stages [25]. In families that have less conflict and more interconnected relationships, there is less burden on caregivers as the whole family can help each other in taking care of the sick or elderly members. In agreement with that, the relationship between married couples can also affect the burden on caregivers, whereas couples with pleasant relationships have shown minimal depression and reported better health, and felt less restrained [25].

Moreover, current findings showed that the monthly income of caregivers has been associated with bodily pain, and this may be one of the factors that affected the working hours of the caregivers and their income. This was consistent with other many studies that reported the relationship between the family income and breast cancer caregivers. Two studies informed that caregivers generally lost paid jobs or decreased their working hours as a result of the caregiving role [17, 26, 27]. Other studies explored the factors associated with QOL among caregivers of the same family members in Addis Ababa, Ethiopia [28]. They showed that a low income can affect and reduce the QOL of caregivers [28]. This finding is consistent with other studies where low income has a critical effect on caregivers' QOL and their ability to fulfill their demands, provide proper support for sufficient treatment, and access or use proper health facilities [17, 28]. In another study that was carried out in India, it was shown that caregivers are exposed to depressive disorders [29], despite the patients' stable health and low income. Spousal caregivers, who provide financial support for care and who reside with the patient, as well as the burden of household chores besides caring for patients, are most affected in this study [29].

In the current study, it was found that the residence/current location elucidates significant contributions to the domains of role limitation because of physical health and emotional problems. Current findings are consistent with a study that showed that the health subscale score was higher among caregivers who were living in the same city [30]. Moreover, other previous studies showed that the caregivers who lived in the urban area had lower QOL [30, 31]. When the hospital and place of living are in the same city, this may enable the caregiver and the patient to be familiar with the environment, so they receive more social support, spend less money, and thus the economic burden may be reduced, and they may also feel less anxiety [30, 31]. Furthermore, this study revealed a relationship between family history of depression with RF, RE, SF, and VT subscales. A previous study showed that caregivers who have a history of mental illness are more likely to experience severe distress or emotional disturbance [32]. As a result, caregivers are likely to become more susceptible to depression and stress, and to developing mental illness as the illness continues [32]. Another study showed that depression has become popular among patients with cancer and can influence the disease course, diagnosis of the disease, personal relationships, and the quality and lifestyle of the whole family [33]. The present study also found that the physical activity of caregivers related to the RF, GH, RE, and MH. These results are consistent with previous research which reported that in families of caregivers, the direct impact of physical activity on emotional distress and physical QOL of caregivers has an indirect impact on mental QOL [34]. Furthermore, depression problems are frequent among patients with breast cancer, consequently, having the potential to influence the prognosis of patients' disease, personal relations, clinical course, and the QOL of all family members. Depression effects on life quality can inversely function by reducing the patient’s-QOL, besides increasing the chance of prevention of recovery in patients as well as poorer prognosis in cancer patients [35, 36]. This has been shown in previous studies in several cancers including breast [3], colorectal [37], and hematological [38].

The present study might have some limitations since it included only two hospitals in Jordan. Besides, it was only conducted over 5 months. Thus, it might be limited in terms of the interventional and care services information that was provided to the patients. Further studies are recommended to examine several medical centers and can probably focus on more aspects of patients' services and interventions.


The age, number of siblings, marital status, monthly income, place of residence, family history of depression, and physical activity are all having a detrimental impact on the life quality of cancer caregivers from the same family. Those caregivers may benefit significantly from different kinds of support, including mental, financial, and home care services which in turn can enhance their QOL.


QOL = Quality of Life
MH = Mental Health


The study was approved by the institutional review board at the Jordan University of Science and Technology, Irbid-Jordan (Approval number 66/2018).


No animals were used in this research. All human research procedures followed were in accordance with the Helsinki Declaration of 1975, as revised in 2013.


Informed consent has been obtained from the study participants.


STROBE guidelines were followed.


Data will be available upon request via e-mailing the corresponding author [S.Y.R].




The authors declare no conflict of interest, financial or otherwise.


Declared none.


[1] Gayatri D, Efremov L, Mikolajczyk R, Kantelhardt EJ. Quality of life assessment and pain severity in breast cancer patients prior to palliative oncology treatment in indonesia: A cross-sectional study. Patient Prefer Adherence 2021; 15: 2017-26.
[2] Sharma R. Global, regional, national burden of breast cancer in 185 countries: evidence from GLOBOCAN 2018. Breast Cancer Res Treat 2021; 187(2): 557-67.
[3] Alquraan L, Alzoubi KH, Rababa’h S, Karasneh R, Al-azzam S, Al-Azayzih A. Prevalence of depression and the quality-of-life of breast cancer patients in jordan. J Multidiscip Healthc 2020; 13: 1455-62.
[4] Chang EWC, Tsai YY, Chang TW, Tsao CJ. Quality of sleep and quality of life in caregivers of breast cancer patient. Psychooncology 2007; 16(10): 950-5.
[5] Haley WE. The costs of family caregiving: implications for geriatric oncology. Crit Rev Oncol Hematol 2003; 48(2): 151-8.
[6] Mor V, Allen S, Malin M. The psychosocial impact of cancer on older versus younger patients and their families. Cancer 1994; 74(S7)(Suppl.): 2118-27.
[7] Pinquart M, Sörensen S. Differences between caregivers and noncaregivers in psychological health and physical health: A meta-analysis. Psychol Aging 2003; 18(2): 250-67.
[8] Haley W, LaMonde LA, Han B, Narramore S, Schonwetter R. Family caregiving in hospice: effects on psychological and health functioning among spousal caregivers of hospice patients with lung cancer or dementia. Hosp J 2001; 15(4): 1-18.
[9] Travis LA, Lyness JM, Shields CG, King DA, Cox C. Social support, depression, and functional disability in older adult primary-care patients. Am J Geriatr Psychiatry 2004; 12(3): 265-71.
[10] Schulz R, O’Brien AT, Bookwala J, Fleissner K. Psychiatric and physical morbidity effects of dementia caregiving: prevalence, correlates, and causes. Gerontologist 1995; 35(6): 771-91.
[11] Hodges LJ, Humphris GM, Macfarlane G. A meta-analytic investigation of the relationship between the psychological distress of cancer patients and their carers. Soc Sci Med 2005; 60(1): 1-12.
[12] Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992; 30(6): 473-83.
[13] García-Batista ZE, Guerra-Peña K, Cano-Vindel A, Herrera-Martínez SX, Medrano LA. Validity and reliability of the Beck Depression Inventory (BDI-II) in general and hospital population of Dominican Republic. PLoS One 2018; 13(6): e0199750-.
[14] Gorji M A H, Bouzar Z, Haghshenas M, Kasaeeyan A A, Sadeghi M R, Ardebil M D J B r n. Quality of life and depression in caregivers of patients with breast cancer. 2012; 5(1): 1-3.
[15] Geng H, Chuang D, Yang F, et al. Prevalence and determinants of depression in caregivers of cancer patients. Medicine (Baltimore) 2018; 97(39): e11863.
[16] Iconomou G, Viha A, Kalofonos HP, Kardamakis D. Impact of cancer on primary caregivers of patients receiving radiation therapy. Acta Oncol 2001; 40(6): 766-71.
[17] Kusi G, Boamah Mensah AB, Boamah Mensah K. The experiences of family caregivers living with breast cancer patients in low-and middle-income countries: a systematic review. Syst Rev 2020; 9(1): 165.
[18] Li Y, Wang K, Yin Y, Li Y, Li S. Relationships between family resilience, breast cancer survivors’ individual resilience, and caregiver burden: A cross-sectional study. Int J Nurs Stud 2018; 88: 79-84.
[19] Öven Ustaalioğlu BB, Acar E. The depression and related factors among cancer patients and their family caregivers in Turkish Population. Acta Oncologica Turcica 2017; 50(2): 115-23.
[20] Nijboer C, Triemstra M, Tempelaar R, Sanderman R, van den Bos GAM. Determinants of caregiving experiences and mental health of partners of cancer patients. Cancer 1999; 86(4): 577-88.
[21] Khanjari S, Langius-Eklöf A, Oskouie F, Sundberg K. Family caregivers of women with breast cancer in Iran report high psychological impact six months after diagnosis. Eur J Oncol Nurs 2014; 18(6): 630-5.
[22] Stenberg U, Ruland CM, Miaskowski C. Review of the literature on the effects of caring for a patient with cancer. Psychooncology 2010; 19(10): 1013-25.
[23] Warning: caring is a health hazard: results of the 1999 national survey of carer health and wellbeing / Carers Association of Australia. Carers Association of Australia,. 2000. [Weston, A.C.T.].
[24] Grbich CF, Maddocks I, Parker D. Family caregivers, their needs, and home-based palliative cancer services. J Fam Stud 2001; 7(2): 171-88.
[25] Northouse LL, Katapodi MC, Schafenacker AM, Weiss D. The impact of caregiving on the psychological well-being of family caregivers and cancer patients. Semin Oncol Nurs 2012; 28(4): 236-45.
[26] Nik Jaafar NR, Selamat Din SH, Mohamed Saini S, et al. Clinical depression while caring for loved ones with breast cancer. Compr Psychiatry 2014; 55(Suppl. 1): S52-9.
[27] Wulandari S, Hermayanti Y, Yamin A, Efendi F. Family Process with Breast Cancer Patient.Indonesia 2017; 12.
[28] Yihedego E, Aga F, Gela D, Boka A. Quality of life and associated factors among family caregivers of adult cancer patients in addis ababa, Ethiopia. Cancer Manag Res 2020; 12: 10047-54.
[29] Sahadevan S, Namboodiri V. Depression in caregivers of patients with breast cancer: A cross-sectional study from a cancer research center in South India. Indian J Psychiatry 2019; 61(3): 277-82.
[30] Gerekeoglu, c.; Korur, A.; Asma, S.; Buyukkurt, N.; Splamz, S.; C., B.; Ozdogu, H., Assessment of Quality of Life in Caregivers of the Patients with Hematologic Neoplasms. Turkish J Fam Med Prim Care 2019; 13(3): 265-72.
[31] Ovayolu Ö, Ovayolu N, Tuna D, Serçe S, Sevinç A, Pirbudak Çöçelli L. Quality of life of caregivers: A cross-sectional study. Int J Nurs Pract 2014; 20(4): 424-32.
[32] Pitceathly C, Maguire P. The psychological impact of cancer on patients’ partners and other key relatives. Eur J Cancer 2003; 39(11): 1517-24.
[33] Thomas C, Morris SM, Harman JC. Companions through cancer. Soc Sci Med 2002; 54(4): 529-44.
[34] Loi SM, Dow B, Ames D, et al. Physical activity in caregivers: What are the psychological benefits? Arch Gerontol Geriatr 2014; 59(2): 204-10.
[35] Sotelo JL, Musselman D, Nemeroff C. The biology of depression in cancer and the relationship between depression and cancer progression. Int Rev Psychiatry 2014; 26(1): 16-30.
[36] Aldea M, Craciun L, Tomuleasa C, Crivii C. The role of depression and neuroimmune axis in the prognosis of cancer patients. J BUON 2014; 19(1): 5-14.
[37] Mhaidat NM, Al-Wedyan TJ, Alzoubi KH, et al. Measuring quality of life among colorectal cancer patients in Jordan. J Palliat Care 2014; 30(3): 133-40.
[38] La Nasa G, Caocci G, Morelli E, et al. Health related quality of life in patients with onco-hematological diseases. Clin Pract Epidemiol Ment Health 2020; 16(1): 174-9.