Dehydroepiandrosterone, Its Sulfate and Cognitive Functions
Karina Junqueira de Menezes1, Clayton Peixoto1, Antonio Egidio Nardi1, Mauro Giovanni Carta2, Sérgio Machado1, André Barciela Veras3, *
Identifiers and Pagination:Year: 2016
First Page: 24
Last Page: 37
Publisher Id: CPEMH-12-24
Article History:Received Date: 20/6/2015
Revision Received Date: 27/9/2015
Acceptance Date: 2/12/2015
Electronic publication date: 29/04/2016
Collection year: 2016
open-access license: This is an open access articles licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided that the work is properly cited.
To present a review of cross-sectional and longitudinal studies that investigate the relationship between the hormones Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone sulfate (DHEA-S) and cognition. Methods: The cognition items included in this review were global cognitive function, memory, attention, executive function, intelligence, perception and visuospatial ability. A systematic review was proceeded using three databases: PubMed, ISI Web of Science, and PsycINFO. Results: Two thousand fifty five references about cognition and hormones were found; 772 duplicated references were excluded, resulting in 1.283 references to be evaluated. According to exclusion and inclusion criteria, 25 references were selected. A positive correlation between DHEA-S blood levels and global cognition was found in women and men. Other positive correlations between DHEA-S and working memory, attention and verbal fluency were found only in women. The DHEA effect on cognition is limited to one study conducted among young men with high-doses.