Comorbidity of Depression and Anxiety: Association with Poor Quality of Life in Type 1 and 2 Diabetic Patients

Ana Claudia C. de Ornelas Maia1, *, Arthur de Azevedo Braga1, Flávia Paes1, Sergio Machado1, 2, 3, 4, Mauro Giovanni Carta5, Antonio Egidio Nardi1, Adriana Cardoso Silva1
1 Laboratory of Panic and Respiration –Institute of Psychiatry of Federal University of Rio de Janeiro, Rio de Janeiro – Brazil, National Institute of Translational Medicine (INCT-TM), Brazil
2 Institute of Phylosophy, Federal University of Uberlândia, Minas Gerais – Brazil
3 Quiropraxia Program of Faculty of Medical Sciences, Central University (UCEN), Santiago, Chile
4 Salgado de Oliveira University, Niterói, Brazil
5 Department of Public Health and Clinical and Molecular Medicine, University of Cagliari, Italy

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© Maia et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Panic and Respiration Laboratory – Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ), Brazil; E-mail:



Diabetes is associates with depression and impairment in Quality of Life (QoL).


The objective is to define the frequencies of depressive and anxiety symptoms in a sample of patients diagnosed with type 1 and 2 diabetes, the amount of impairment of QoL and the weight of depression and anxiety in determining the QoL in such of patients.


A total of 210 patients were divided into two groups (type 1 and type 2). Patients completed the HADS and WHOQoL-bref.


Groups showed a high prevalence of anxiety (type 1 = 60%, type 2 = 43.8%) and depression (type 1 = 52.4%, type 2 = 38.1%), both measures were significantly higher (p < 0.05) in diabetes type 1 patients. Type 1 patients also showed a QoL in the overall assessment and the physical, psychological and social relations domains. In both Type 1 and 2 diabetes poor QoL was found associated by anxiety and depression comorbidity.


In overall diabetes patients depression and anxiety seems to be a determinant of poor QoL.

Keywords: : Anxiety, depression, quality of life, type 1 and type 2 diabetes.