Emotional Disturbances and Crohn's Disease

This review aims to explore the psychological, psychiatric, and neurocognitive dimensions of Crohn’s disease. We examine the bidirectional interactions between the gut and brain, analyze the most widely used psychological assessment tools, and discuss current intervention models.

A comprehensive narrative review was conducted, integrating the literature research findings of , psychosomatic medicine, neuropsychology, psychoneuroimmunology, and gut-brain axis. Attention was given to validated psychometric tools and emerging therapeutic approaches.

The evidence reveals a consistent link between CD and emotional disturbances, cognitive deficits, and altered gut-brain communication. Common neuropsychological impairments include deficits in attention, memory, and executive functioning. Anxiety, depression, and alexithymia are prevalent in CD patients and are associated with worse disease outcomes. Cognitive Behavioral Therapy (CBT), Acceptance and Commitment Therapy (ACT), and mindfulness-based interventions have demonstrated efficacy in enhancing both psychological well-being and disease management.

Findings confirm the link between Crohn’s disease, emotional disturbances, and cognitive deficits, highlighting the need to distinguish between primary impairments of inflammatory/neurobiological origin and those secondary to psychological distress or low illness insight. Key gaps remain regarding how these mechanisms interact over time and the long-term effects of psychological interventions. Integrating psychological assessment and support into clinical care is crucial for enhancing adherence, resilience, and overall quality of life.

Understanding CD through a biopsychosocial lens highlights the necessity of integrating psychological assessment and intervention into standard IBD care. Early identification and tailored treatment of emotional and cognitive disturbances can significantly improve patients’ quality of life and overall clinical outcomes.