Relationship Between Brain-Derived Neurotrofic Factor (Bdnf) and Sleep on Depression: A Critical Review
Bárbara C. Monteiro1, Suzana Monteiro1, Maristela Candida1, Nathalia Adler1, Flavia Paes1, Nuno Rocha2, 4, Antonio Egidio Nardi1, Eric Murillo-Rodriguez3, 4, Sergio Machado1, 4, 5, *
Identifiers and Pagination:Year: 2017
First Page: 213
Last Page: 219
Publisher ID: CPEMH-13-213
Article History:Received Date: 8/06/2017
Revision Received Date: 11/10/2017
Acceptance Date: 22/10/2017
Electronic publication date: 21/11/2017
Collection year: 2017
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The Brain-Derived Neurotrofic Factor (BDNF) is one of the most important neurotrophins in the brain and it is suggested influences the activity of the serotonergic, noradrenergic and dopaminergic pathways. In the last few years, it has been hypothesized that BDNF level is related with depression and sleep. Several studies show that depressive subjects present low levels of BDNF in the brain. Poor sleep quality is also related with alterations in the BDNF concentration. Some authors argue that most of the cases show that impaired sleep quality increases the stress and, consequently, the vulnerability to depressive disorders, suggesting that there is a relationship between sleep, depression and BDNF levels.